Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257574 | 0.87 | RAB9A (0.45) | ALDH1A1POLBNPC1RAB9AMAPT | |
| SCHEMBL14267805 | 0.85 | SMN1; SMN2 (0.35) | KMT2AALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL14257481 | 0.85 | LMNA (0.39) | KMT2AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL14257651 | 0.85 | KMT2A (0.41) | KMT2AMEN1ALDH1A1NPSR1POLB | |
| SCHEMBL14258949 | 0.85 | KMT2A (0.41) | KMT2AMEN1ALDH1A1NPSR1POLB | |
| SCHEMBL3644300 | 0.84 | KMT2A (0.47) | KMT2AMEN1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL14257534 | 0.84 | KMT2A (0.47) | KMT2AMEN1ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL13240726 | 0.80 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL14257580 | 0.79 | NPC1 (0.46) | KMT2AALDH1A1L3MBTL1NPSR1POLB | |
| SCHEMBL14257545 | 0.79 | FAAH (0.41) | KMT2AMEN1ALDH1A1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | ABBOTT LABORATORIES | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076924-A1 | Piperazines as P2X7 antagonists | P2RX7, P2RX1, P2RX2 | KMT2A 3643/4885MEN1 4288/4885ALDH1A1 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.