Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 6/20 | 0.54 |
| ▸ | MAOA | P21397 | 5/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364428 | 0.90 | MAOB (0.54) | KDM4ETSHRMAOBMAOABCHE | |
| SCHEMBL29658517 | 0.84 | CHRNB2 (0.59) | KDM4EMAOBMAOABCHEACHE | |
| SCHEMBL901802 | 0.84 | CHRNB2 (0.59) | KDM4EMAOBMAOABCHEACHE | |
| SCHEMBL9706141 | 0.84 | KDM4E (0.73) | KDM4ETSHRMAOBMAPTCHRNA7 | |
| SCHEMBL910596 | 0.82 | MAOA (0.58) | KDM4ETSHRMAOBMAOAMAPT | |
| SCHEMBL870305 | 0.82 | CYP1A2 (0.61) | MAOBBCHEACHEMAPTCHRNA7 | |
| SCHEMBL29955687 | 0.82 | MAOA (0.58) | KDM4ETSHRMAOBMAOAMAPT | |
| SCHEMBL5543437 | 0.82 | MAOA (0.66) | MAOBMAOAKMT2ANPC1RAB9A | |
| SCHEMBL30409096 | 0.81 | TLR4 (0.64) | TSHRMAOBMAOAMAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5692419 | 0.81 | CYP1A2 (0.59) | MAOBBCHEACHEMAPTCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300440-B1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-27 | — | — | EP | disclosed |
| US-20110124666-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | Janssen Pharmaceutica NV a corporation | 2011-05-26 | — | — | US | disclosed |
| EP-2300440-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009147079-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-12-10 | — | — | WO | disclosed |
| US-RE39708-E1 | Estrogen receptor modulators | CHIRON CORPORATION (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1102753-B1 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-6869969-B2 | Estrogen receptor modulators | CHIRON CORPORATION (US) | 2005-03-22 | — | — | US | disclosed |
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | HUSSON HENRI-PHILIPPE (FR) | 2004-09-16 | — | — | US | disclosed |
| US-6743815-B2 | OSTEOPOROSIS; ENDOMETRIOSIS; ALZHEIMER'S DISEASE | CHIRON CORPORATION | 2004-06-01 | — | — | US | disclosed |
| US-20040102498-A1 | Cycloalkylene compounds with substituents as anticancer agents, atheriosclerosis and estrogen receptors | CHIRON CORPORATION | 2004-05-27 | — | — | US | disclosed |
| US-6262098-B1 | ISOXAZOLE ESTROGEN RECEPTOR AGONIST AND ANTAGONIST | CHIRON CORPORATION | 2001-07-17 | — | — | US | disclosed |
| EP-1102753-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| EP-1102755-A1 | SUBSTITUTED ISOXAZOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007996-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |
| WO-2000008001-A1 | SUBSTITUTED ISOXAZOLE AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |
| US-4478598-A | FOR TEXTILES AND IN LAUNDRY DETERGENTS | CIBA-GEIGY CORPORATION (US) | 1984-10-23 | — | — | US | disclosed |
| US-4336374-A | HYPOGLYCEMIC AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1982-06-22 | — | — | US | disclosed |
| US-4053514-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4038274-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-3969527-A | INDENO(1,2-C)PYRAZOLE | E. R. SQUIBB & SONS, INC. (US) | 1976-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180917-A1 | Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same | SCN11A, CYP4A11, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KDM4E 4257/4885TSHR 2272/4885MAOB 569/4885 |
| US-20110124666-A1 | 3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS | TRPA1, TRPV1, TRPV3 | KDM4E 4538/4885TSHR 2309/4885MAOB 3054/4885 |
| US-20040102498-A1 | Cycloalkylene compounds with substituents as anticancer agents, atheriosclerosis and estrogen receptors | ESR2, GPER1, ESR1 | KDM4E 3177/4885TSHR 557/4885MAOB 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.