Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16059596 | 0.88 | NPC1 (0.59) | NPC1RAB9AGPR55KMT2AALDH1A1 | |
| SCHEMBL1337005 | 0.80 | NPC1 (0.59) | NPC1RAB9AGPR55KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL1336911 | 0.79 | NPC1 (0.58) | NPC1RAB9AGPR55KMT2AALDH1A1 | |
| SCHEMBL8320959 | 0.72 | SMN1; SMN2 (0.49) | RAB9AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL11195714 | 0.72 | MEN1 (0.46) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL18291578 | 0.71 | POLB (0.50) | KMT2AMEN1POLBGAAOXTR | |
| SCHEMBL18291592 | 0.71 | POLB (0.50) | KMT2AMEN1POLBGAAOXTR | |
| SCHEMBL12443455 | 0.71 | PDE4A (0.47) | KMT2AALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL16316832 | 0.71 | OXTR (0.38) | NPC1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL18291743 | 0.71 | OXTR (0.48) | KMT2AMEN1POLBGAAOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332492-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
| US-7332492-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |