Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 6/20 | 0.43 |
| ▸ | RGS8 | P57771 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | LGMN | Q99538 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280878 | 0.86 | HPGD (0.43) | RGS4RGS8CYP3A4HPGDGSK3A | |
| SCHEMBL30272686 | 0.70 | HPGD (0.50) | RGS4RGS8CYP3A4HPGDGSK3A | |
| SCHEMBL8985073 | 0.69 | GSK3B (0.67) | RGS4RGS8CYP3A4HPGDGSK3A | |
| SCHEMBL3940708 | 0.68 | HPGD (0.64) | CYP3A4HPGDGSK3AGSK3BCCNB2 | |
| SCHEMBL14280876 | 0.65 | MIF (0.48) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL6312537 | 0.64 | MAPK8 (0.49) | RGS4RGS8GSK3AGSK3BCCNB2 | |
| SCHEMBL4490611 | 0.64 | ROCK2 (0.53) | RGS4RGS8CYP3A4HPGDGSK3A | |
| SCHEMBL14280875 | 0.63 | MIF (0.46) | GSK3AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL14280868 | 0.63 | DDB1 (0.47) | HPGDGSK3AGSK3BKMT2AALDH1A1 | |
| SCHEMBL7519636 | 0.62 | KMT2A (0.52) | RGS4RGS8CYP3A4HPGDGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021079-A1 | Compounds, Compositions, and Methods | CYTOKINETICS, INC. | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021079-A1 | Compounds, Compositions, and Methods | ALPP, PCNA, MKI67 | RGS4 4299/4885RGS8 3473/4885CYP3A4 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.