Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282935 | 0.93 | ALDH1A1 (0.43) | ALDH1A1MAPTKMT2ADRD2DRD4 | |
| SCHEMBL4697602 | 0.90 | ALDH1A1 (0.46) | ALDH1A1KMT2ADRD2DRD4HTR2A | |
| SCHEMBL14282934 | 0.88 | DRD2 (0.47) | ALDH1A1MAPTKMT2ADRD2DRD4 | |
| SCHEMBL14282933 | 0.82 | DRD2 (0.43) | KMT2ADRD2DRD4HTR2AHTR2C | |
| SCHEMBL14282938 | 0.76 | BCHE (0.53) | ALDH1A1MAPTKMT2ADRD2DRD4 | |
| SCHEMBL14198340 | 0.76 | SETD7 (0.57) | ALDH1A1MAPTKMT2AHTR7OPRD1 | |
| SCHEMBL4563119 | 0.76 | OPRD1 (0.54) | ALDH1A1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL4081229 | 0.75 | OPRD1 (0.50) | ALDH1A1MAPTKMT2AHTR7OPRD1 | |
| SCHEMBL14198374 | 0.73 | SETD7 (0.58) | ALDH1A1MAPTKMT2AHTR7OPRD1 | |
| SCHEMBL4693876 | 0.73 | OPRD1 (0.48) | ALDH1A1MAPTKMT2AHTR7OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |