Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282933 | 0.93 | DRD2 (0.43) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282936 | 0.88 | ALDH1A1 (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282935 | 0.82 | ALDH1A1 (0.43) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL4697602 | 0.77 | ALDH1A1 (0.46) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282960 | 0.75 | BCHE (0.50) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282904 | 0.75 | OPRD1 (0.50) | OPRD1OPRK1OPRM1MEN1POLB | |
| SCHEMBL4257154 | 0.74 | SETD7 (0.56) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL11036336 | 0.72 | SETD7 (0.53) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL5185766 | 0.70 | KMT2A (0.59) | MEN1POLBKMT2ALMNAMAPT | |
| SCHEMBL24177749 | 0.70 | KDM4E (0.42) | MEN1POLBKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |