Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 4/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282934 | 0.93 | DRD2 (0.47) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282935 | 0.89 | ALDH1A1 (0.43) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282936 | 0.82 | ALDH1A1 (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282954 | 0.76 | BCHE (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14559349 | 0.76 | BCHE (0.48) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL4697602 | 0.73 | ALDH1A1 (0.46) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL14282904 | 0.73 | OPRD1 (0.50) | OPRD1OPRM1OPRK1HTR7SETD7 | |
| SCHEMBL4257154 | 0.73 | SETD7 (0.56) | DRD2DRD4HTR2AHTR2CHTR2B | |
| SCHEMBL21886707 | 0.72 | CHRNA7 (0.54) | CTSLMEN1POLBKMT2A | |
| SCHEMBL22101385 | 0.72 | CHRNA7 (0.54) | CTSLMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |