Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12068383 | 0.74 | KDM4E (0.50) | KDM4EGAAMAPTALDH1A1AMY1A | |
| SCHEMBL29445571 | 0.73 | APP (0.70) | KDM4ETHRBBLMMEN1KMT2A | |
| SCHEMBL12488031 | 0.73 | APP (0.70) | KDM4ETHRBBLMMEN1KMT2A | |
| SCHEMBL106725 | 0.73 | APP (0.70) | KDM4ETHRBBLMMEN1KMT2A | |
| SCHEMBL29365544 | 0.73 | APP (0.70) | KDM4ETHRBBLMMEN1KMT2A | |
| SCHEMBL8320381 | 0.73 | NQO2 (0.45) | KDM4EMAPK1ALDH1A1AMY1ATSHR | |
| SCHEMBL28998075 | 0.70 | KMT2A (0.66) | KDM4ENPC1MAPK1GAAMAPT | |
| Acridine SCHEMBL28132121 | 0.70 | APP (0.60) | KDM4ETHRBBLMMEN1KMT2A | |
| SCHEMBL12068392 | 0.69 | ALDH1A1 (0.57) | KDM4ENPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL278565 | 0.69 | NCF1 (0.56) | KDM4ENPC1MAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174993-A1 | PROBE LIBRARY CONSTRUCTION | President and Fellows of Harvard College (US) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016018963-A9 | PROBE LIBRARY CONSTRUCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016018963-A1 | PROBE LIBRARY CONSTRUCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-02-04 | — | — | WO | disclosed |
| CN-102686997-B | Single molecule detection system and method | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (CN) | 2014-10-29 | — | — | CN | disclosed |
| CN-102686997-A | Single molecule detection system and method | IND TECH RES INST | 2012-09-19 | — | — | CN | disclosed |
| EP-2313516-A1 | COMPOSITIONS AND METHODS FOR MODULATING NOD-LIKE RECEPTOR ACTIVITY AND USES THEREOF | Burnham Institute for Medical Research (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-2300801-A1 | APPARATUS AND METHOD FOR DETECTION AND DISCRIMINATION MOLECULAR OBJECT | Industrial Technology Research Institute (TW) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010102567-A1 | APPARATUS AND METHOD FOR DETECTION AND DISCRIMINATION MOLECULAR OBJECT | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (CN) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010009350-A2 | COMPOSITIONS AND METHODS FOR MODULATING NOD-LIKE RECEPTOR ACTIVITY AND USES THEREOF | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-01-21 | — | — | WO | disclosed |
| US-6982252-B2 | Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2006-01-03 | — | — | US | disclosed |
| WO-2003047350-A1 | INHIBITION OF VACUOLAR PROTON ATPASE AND/OR MODULATION OF ACIDIC ORGANELLE FUNCTION SENSITIZES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2003-06-12 | — | — | WO | disclosed |
| US-20020156025-A1 | Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156025-A1 | Inhibition of vacuolar proton ATPase activity and/or the modulation of acidic organelle function sensitizes cells to radiation, chemotherapy and biological agents | ATP6V1H, ATP6V1E1, ATP6AP1 | KDM4E 4066/4885NPC1 1692/4885MAPK1 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.