Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 12/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600769 | 0.82 | CCNE2 (0.34) | RPS6KA3PTGESCCNE2CCNE1CDK2 | |
| SCHEMBL14286161 | 0.73 | ALDH1A1 (0.36) | MAPK7MAPK14PTGESYTHDC1 | |
| SCHEMBL14286160 | 0.68 | CHRM1 (0.42) | ROCK2GSK3BROCK1 | |
| SCHEMBL14286157 | 0.66 | MAPK1 (0.56) | GSK3B | |
| SCHEMBL10067972 | 0.64 | KCNN4 (0.34) | RPS6KA3DYRK1ADCLK1DYRK3ROCK2 | |
| SCHEMBL14286146 | 0.64 | ADRA2A (0.37) | MAPK7MAPK14PTGESCDK2CCNC | |
| SCHEMBL6825870 | 0.62 | NPC1 (0.54) | — | |
| SCHEMBL1126571 | 0.61 | FGFR3 (0.42) | PTGES | |
| SCHEMBL14310378 | 0.61 | PTGES (0.37) | MAPK7PTGESCDK2 | |
| SCHEMBL5038382 | 0.59 | MAPK1 (0.49) | DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |