Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 14/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286161 | 0.82 | ALDH1A1 (0.36) | KCNN4LMNAALDH1A1KMT2APTGES | |
| SCHEMBL14600771 | 0.73 | ADRA2A (0.37) | LMNAALDH1A1KMT2ARPS6KA3PTGES | |
| SCHEMBL14600769 | 0.72 | CCNE2 (0.34) | CCNE2CCNE1CDK2FAAHRPS6KA3 | |
| SCHEMBL10067969 | 0.69 | HRH4 (0.35) | KCNN4LMNAALDH1A1 | |
| SCHEMBL10067973 | 0.66 | RAB9A (0.51) | LMNAALDH1A1KMT2AGSK3BNPC1 | |
| SCHEMBL10067396 | 0.66 | NPC1 (0.48) | LMNAALDH1A1KMT2AIRAK4NPC1 | |
| SCHEMBL14286146 | 0.64 | ADRA2A (0.37) | CDK2PTGES | |
| SCHEMBL14286152 | 0.64 | MAPK7 (0.37) | CCNE2CCNE1CDK2DCLK1DYRK3 | |
| SCHEMBL10067970 | 0.63 | PTGES (0.39) | CDK2LMNAALDH1A1NPC1PTGES | |
| SCHEMBL5042176 | 0.63 | ALDH1A1 (0.39) | KCNN4LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697352-B1 | 4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE | VERTEX PHARMA (US) | 2012-06-27 | — | — | EP | disclosed |
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |