Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11921165 | 0.76 | EGFR (0.39) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL10327299 | 0.75 | CYP1A2 (0.50) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL14289099 | 0.74 | HSP90AA1 (0.35) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL12371084 | 0.73 | HCAR2 (0.37) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL3765970 | 0.71 | MAPT (0.43) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL11195631 | 0.70 | MAPT (0.57) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL12132912 | 0.69 | ALDH1A1 (0.40) | MAPTKDM4EHSP90AA1KMT2ACYP3A4 | |
| SCHEMBL9928498 | 0.69 | MAPT (0.52) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL24174568 | 0.69 | NPC1 (0.35) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL12397278 | 0.69 | HCAR2 (0.35) | MAPTKDM4EHSP90AA1NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | METHYLGENE, INC. (CA) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | HGF, ERBB2, MET | MAPT 1806/4885KDM4E 2282/4885HSP90AA1 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.