Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CCR8 | P51685 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22792600 | 0.76 | HSP90AA1 (0.34) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL12733328 | 0.76 | EGFR (0.41) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL9058058 | 0.75 | KDM4E (0.50) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL16626082 | 0.75 | HSP90AA1 (0.43) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL14289098 | 0.74 | MAPT (0.39) | HSP90AA1NPC1L3MBTL1KDM4ELMNA | |
| SCHEMBL22131166 | 0.73 | PRMT5 (0.41) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL10327299 | 0.71 | CYP1A2 (0.50) | LMNAMAPTHTTCYP2D6SMN1; SMN2 | |
| SCHEMBL14314008 | 0.70 | PDE4A (0.38) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL324632 | 0.70 | KDM4E (0.41) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E | |
| SCHEMBL14289097 | 0.69 | TGFBR1 (0.35) | HSP90AA1NPC1L3MBTL1PRMT5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | METHYLGENE, INC. (CA) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | HGF, ERBB2, MET | HSP90AA1 898/4885NPC1 3563/4885L3MBTL1 3690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.