Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313002 | 0.86 | HPGDS (0.41) | SLC22A12JAK2JAK1TYK2JAK3 | |
| SCHEMBL14313417 | 0.86 | MET (0.39) | HPGDSCSNK1DWNT3AMETHDAC3 | |
| SCHEMBL3217942 | 0.85 | JAK2 (0.41) | SLC22A12JAK2JAK1TYK2JAK3 | |
| SCHEMBL14312771 | 0.84 | GRIN2B (0.38) | SLC22A12HPGDSWNT3AMETBCHE | |
| SCHEMBL14312729 | 0.84 | MET (0.39) | HPGDSCSNK1DWNT3AMETHDAC1 | |
| SCHEMBL14312654 | 0.81 | HPGDS (0.39) | SLC22A12HPGDSPARP1 | |
| SCHEMBL14312791 | 0.79 | NR3C2 (0.36) | HPGDSWNT3AMETHDAC1HDAC6 | |
| SCHEMBL3221574 | 0.78 | HPGDS (0.53) | SLC22A12JAK2JAK1TYK2JAK3 | |
| SCHEMBL14312803 | 0.78 | MET (0.39) | HPGDSMET | |
| SCHEMBL14312907 | 0.78 | PTGS2 (0.39) | HPGDSMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |