Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313107 | 0.93 | SLC22A12 (0.33) | SLC22A12HPGDSTGFBR1TGFBR2 | |
| SCHEMBL14313355 | 0.92 | TGFBR1 (0.35) | SLC22A12MAPTHPGDSTGFBR1TGFBR2 | |
| SCHEMBL14313271 | 0.87 | MAPT (0.33) | SLC22A12MAPTHPGDS | |
| SCHEMBL14312659 | 0.86 | HPGDS (0.34) | HPGDS | |
| SCHEMBL3230591 | 0.85 | HPGDS (0.45) | SLC22A12MAPTHPGDSTGFBR1TGFBR2 | |
| SCHEMBL14313094 | 0.84 | TGFBR1 (0.35) | SLC22A12MAPTHPGDSTGFBR1TGFBR2 | |
| SCHEMBL14313345 | 0.84 | HPGDS (0.35) | HPGDS | |
| SCHEMBL14313192 | 0.84 | SLC22A12 (0.34) | SLC22A12HPGDS | |
| SCHEMBL14312827 | 0.83 | PTGER1 (0.30) | — | |
| SCHEMBL14313038 | 0.83 | HPGDS (0.35) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |