Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 3/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313270 | 0.93 | HPGDS (0.32) | HPGDSAGTR2ECE1SLC22A12 | |
| SCHEMBL14313355 | 0.88 | TGFBR1 (0.35) | MAPTHPGDSSLC22A12 | |
| SCHEMBL14312739 | 0.87 | SLC22A12 (0.33) | MAPTHPGDSSLC22A12 | |
| SCHEMBL14313453 | 0.85 | HPGDS (0.35) | HPGDSECE1 | |
| SCHEMBL14312960 | 0.84 | HPGDS (0.36) | MAPTHPGDS | |
| SCHEMBL3222736 | 0.83 | HPGDS (0.47) | MAPTHPGDSSLC22A12 | |
| SCHEMBL14313174 | 0.83 | HPGDS (0.36) | HPGDSECE1 | |
| SCHEMBL14312879 | 0.83 | ENPP3 (0.36) | HPGDSECE1SLC22A12 | |
| SCHEMBL14313272 | 0.82 | AGTR2 (0.30) | AGTR2 | |
| SCHEMBL14313311 | 0.82 | HPGDS (0.47) | MAPTHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |