Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313099 | 0.92 | TGFBR1 (0.36) | SLC22A12ENPP3ENPP1MTNR1APARP1 | |
| SCHEMBL14312879 | 0.87 | ENPP3 (0.36) | SLC22A12ENPP3ENPP1MTNR1APARP1 | |
| SCHEMBL14312613 | 0.86 | HPGDS (0.34) | HPGDS | |
| SCHEMBL3210289 | 0.85 | HPGDS (0.45) | SLC22A12ENPP3ENPP1SLC22A6ABCG2 | |
| SCHEMBL14312739 | 0.84 | SLC22A12 (0.33) | SLC22A12HPGDS | |
| SCHEMBL14313107 | 0.84 | SLC22A12 (0.33) | SLC22A12HPGDS | |
| SCHEMBL14313173 | 0.83 | PDE4A (0.30) | — | |
| SCHEMBL14312748 | 0.82 | HPGDS (0.37) | HPGDSL3MBTL1 | |
| SCHEMBL14313406 | 0.82 | — | — | |
| SCHEMBL14312671 | 0.82 | HPGDS (0.46) | SLC22A12HPGDSL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |