Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312696 | 0.88 | HPGDS (0.43) | HPGDSMAPTCSNK1DHCRTR2WNT3A | |
| SCHEMBL14313193 | 0.86 | HPGDS (0.40) | HPGDSTP53PSEN1PSEN2APH1B | |
| SCHEMBL3220698 | 0.85 | HPGDS (0.54) | HPGDSTP53METCSNK1DALDH1A1 | |
| SCHEMBL14313255 | 0.84 | HPGDS (0.42) | HPGDSMETMAPTCSNK1DHCRTR2 | |
| SCHEMBL14312798 | 0.84 | HPGDS (0.42) | HPGDSMETMAPTCSNK1DHCRTR2 | |
| SCHEMBL14312563 | 0.82 | HPGDS (0.41) | HPGDSMAPTCSNK1DWNT3A | |
| SCHEMBL14313134 | 0.82 | HPGDS (0.41) | HPGDSMETCSNK1DWNT3APDGFRB | |
| SCHEMBL14313344 | 0.81 | HPGDS (0.40) | HPGDSMAPTCSNK1DHCRTR2WNT3A | |
| SCHEMBL14313439 | 0.81 | HPGDS (0.54) | HPGDSMAPTCSNK1DHCRTR2WNT3A | |
| SCHEMBL14312983 | 0.80 | HPGDS (0.40) | HPGDSTP53METMAPTHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |