Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312885 | 0.87 | HPGDS (0.49) | HPGDSCDC7CDK2MAPTNPSR1 | |
| SCHEMBL12083914 | 0.85 | HPGDS (0.51) | HPGDSMAPK8MAPK9MAPK10SYK | |
| SCHEMBL14313271 | 0.84 | MAPT (0.33) | HPGDSMAPT | |
| SCHEMBL14312699 | 0.84 | HPGDS (0.37) | HPGDS | |
| SCHEMBL14312581 | 0.84 | HPGDS (0.51) | HPGDS | |
| SCHEMBL14313340 | 0.83 | MAPK9 (0.35) | HPGDSMAPK8MAPK9MAPK10SCN9A | |
| SCHEMBL14313270 | 0.82 | HPGDS (0.32) | HPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL14312407 | 0.81 | HPGDS (0.39) | HPGDSMAPT | |
| SCHEMBL14312864 | 0.79 | HPGDS (0.39) | HPGDSNPSR1S1PR1 | |
| SCHEMBL14312879 | 0.79 | ENPP3 (0.36) | HPGDSNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |