Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313099 | 0.88 | TGFBR1 (0.36) | ENPP3SLC22A12ENPP1MTNR1APARP1 | |
| SCHEMBL14313192 | 0.87 | SLC22A12 (0.34) | ENPP3SLC22A12ENPP1MTNR1APARP1 | |
| SCHEMBL14312689 | 0.85 | HPGDS (0.35) | ALDH1A1HPGDKDM4EHPGDSECE1 | |
| SCHEMBL3219959 | 0.83 | HPGDS (0.47) | ENPP3SLC22A12ENPP1MTNR1APARP1 | |
| SCHEMBL14312671 | 0.83 | HPGDS (0.46) | SLC22A12ALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL14313270 | 0.83 | HPGDS (0.32) | SLC22A12HPGDSECE1 | |
| SCHEMBL14313271 | 0.83 | MAPT (0.33) | SLC22A12HPGDSECE1 | |
| SCHEMBL14313288 | 0.82 | KDM4E (0.31) | ALDH1A1HPGDKDM4E | |
| SCHEMBL14312631 | 0.82 | KDM4E (0.31) | ALDH1A1HPGDKDM4E | |
| SCHEMBL14313264 | 0.82 | HPGDS (0.38) | ALDH1A1HPGDKDM4EHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |