Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313002 | 0.90 | HPGDS (0.41) | HPGDSCSNK1DPSEN1PSEN2APH1B | |
| SCHEMBL14313255 | 0.88 | HPGDS (0.42) | HPGDSCSNK1DPSEN1PSEN2APH1B | |
| SCHEMBL14312798 | 0.86 | HPGDS (0.42) | HPGDSCSNK1DPSEN1PSEN2APH1B | |
| SCHEMBL14313022 | 0.84 | HPGDS (0.45) | HPGDSMAPTLMNA | |
| SCHEMBL12084232 | 0.84 | HPGDS (0.54) | HPGDSCSNK1DWNT3AMAPK14MAPT | |
| SCHEMBL14312563 | 0.84 | HPGDS (0.41) | HPGDSCSNK1DWNT3AMAPT | |
| SCHEMBL14313344 | 0.83 | HPGDS (0.40) | HPGDSCSNK1DPSEN1PSEN2APH1B | |
| SCHEMBL14312696 | 0.83 | HPGDS (0.43) | HPGDSCSNK1DPSEN1PSEN2APH1B | |
| SCHEMBL14312983 | 0.82 | HPGDS (0.40) | HPGDSPDGFRBPDGFRAMAPTLMNA | |
| SCHEMBL14313134 | 0.82 | HPGDS (0.41) | HPGDSCSNK1DPDGFRBPDGFRAWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |