Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313324 | 0.93 | TGFBR1 (0.34) | HPGDSCES2 | |
| SCHEMBL14312554 | 0.89 | CES2 (0.30) | CES2 | |
| SCHEMBL14312794 | 0.89 | HPGDS (0.31) | HPGDSCES2 | |
| SCHEMBL14312939 | 0.88 | HPGDS (0.34) | HPGDS | |
| SCHEMBL14312748 | 0.88 | HPGDS (0.37) | HPGDS | |
| SCHEMBL14312910 | 0.88 | HPGDS (0.40) | HPGDSCES2 | |
| SCHEMBL14312613 | 0.87 | HPGDS (0.34) | HPGDS | |
| SCHEMBL14313051 | 0.87 | PTGER1 (0.33) | — | |
| SCHEMBL14312736 | 0.87 | PTGER1 (0.31) | HPGDS | |
| SCHEMBL14313173 | 0.84 | PDE4A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |