Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313406 | 0.93 | — | — | |
| SCHEMBL14312986 | 0.93 | TGFBR1 (0.35) | PDE4AKDM4EALDH1A1HPGDKCNH2 | |
| SCHEMBL14312613 | 0.90 | HPGDS (0.34) | PDE4AKDM4EALDH1A1HPGD | |
| SCHEMBL14313288 | 0.88 | KDM4E (0.31) | PDE4AKDM4EALDH1A1HPGDKCNH2 | |
| SCHEMBL14312748 | 0.86 | HPGDS (0.37) | KDM4E | |
| SCHEMBL14312554 | 0.86 | CES2 (0.30) | — | |
| SCHEMBL14312735 | 0.85 | TGFBR1 (0.35) | KDM4EALDH1A1HPGD | |
| SCHEMBL14312827 | 0.85 | PTGER1 (0.30) | — | |
| SCHEMBL14312784 | 0.85 | NTRK1 (0.31) | — | |
| SCHEMBL14313158 | 0.84 | HPGDS (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |