Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | CLPP | Q16740 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | TCF7 | P36402 | 2/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | TCF4 | P15884 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14319416 | 0.97 | CTNNB1 (0.48) | HCRTR1HCRTR2CLPPCTNNB1TCF7 | |
| SCHEMBL14309868 | 0.90 | MEN1 (0.51) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14504798 | 0.89 | HCRTR1 (0.42) | HCRTR1HCRTR2CLPPCTNNB1TCF7 | |
| SCHEMBL14309426 | 0.89 | CLPP (0.51) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14319413 | 0.89 | PDE4A (0.40) | HCRTR1HCRTR2CYP3A4NPC1TP53 | |
| SCHEMBL17572593 | 0.88 | CYP3A4 (0.44) | HCRTR1HCRTR2CLPPCYP3A4 | |
| SCHEMBL14319418 | 0.87 | CLPP (0.45) | HCRTR1HCRTR2CLPPCTNNB1TCF7 | |
| SCHEMBL14309886 | 0.87 | CLPP (0.48) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14319440 | 0.87 | CLPP (0.47) | CLPPCTNNB1TCF7BCL9TCF4 | |
| SCHEMBL14309878 | 0.87 | CTNNB1 (0.54) | CLPPCTNNB1TCF7BCL9TCF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957516-B1 | ALFA-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS | CHOONGWAE PHARMA CORP (KR) | 2016-03-09 | — | — | EP | disclosed |
| US-20080009500-A1 | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders | INSTITUTE FOR CHEMICAL GENOMICS | 2008-01-10 | — | — | US | disclosed |
| US-20070129353-A1 | Alpha-helix mimetics and method relating to the treatment of cancer stem cells | INSTITUTE FOR CHEMICAL GENOMICS | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009500-A1 | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders | COL1A1, COL2A1, PLOD3 | HCRTR1 3564/4885HCRTR2 3733/4885CLPP 2188/4885 |
| US-20070129353-A1 | Alpha-helix mimetics and method relating to the treatment of cancer stem cells | MCL1, HNF4A, THPO | HCRTR1 3838/4885HCRTR2 4295/4885CLPP 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.