Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8585253 | 0.86 | TRPM8 (0.43) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| SCHEMBL7606663 | 0.84 | TRPM8 (0.44) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10629698 | 0.79 | TRPM8 (0.42) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL8602843 | 0.79 | TRPM8 (0.42) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| Bromide SCHEMBL9486638 | 0.77 | TRPM8 (0.38) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| Bromide SCHEMBL2472545 | 0.76 | TRPM8 (0.42) | OPRM1TRPA1TRPM8ALDH1A1CYP3A4 | |
| SCHEMBL11146809 | 0.75 | TRPM8 (0.41) | OPRM1TRPA1TRPM8ALDH1A1 | |
| SCHEMBL10976094 | 0.75 | TRPM8 (0.41) | OPRM1TRPA1TRPM8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1580278 | 0.74 | MEN1 (0.46) | OPRM1TRPM8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9418652 | 0.74 | ALDH1A1 (0.34) | OPRM1TRPA1TRPM8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140303066-A1 | STABLE POLYMER CONTAINING TWO PHASE SYSTEMS | PROCTER & GAMBLE (US) | 2014-10-09 | — | — | US | disclosed |
| EP-2723846-A1 | STABLE POLYMER CONTAINING TWO PHASE SYSTEMS | The Procter and Gamble Company (US) | 2014-04-30 | — | — | EP | disclosed |
| WO-2013003426-A1 | STABLE POLYMER CONTAINING TWO PHASE SYSTEMS | THE PROCTER & GAMBLE COMPANY (US) | 2013-01-03 | — | — | WO | disclosed |
| US-20120329697-A1 | STABLE POLYMER CONTAINING TWO PHASE SYSTEMS | THE PROCTER & GAMBLE COMPANY | 2012-12-27 | — | — | US | disclosed |