Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606663 | 0.98 | TRPM8 (0.44) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Bromide SCHEMBL9486638 | 0.90 | TRPM8 (0.38) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Hydrochloric Acid SCHEMBL8602843 | 0.89 | TRPM8 (0.42) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Hydrochloric Acid SCHEMBL10629698 | 0.89 | TRPM8 (0.42) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Hydrochloric Acid SCHEMBL9418652 | 0.86 | ALDH1A1 (0.34) | TRPM8TRPA1OPRM1ALDH1A1CYP19A1 | |
| Bromide SCHEMBL2472545 | 0.86 | TRPM8 (0.42) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Hydrochloric Acid SCHEMBL14320259 | 0.86 | OPRM1 (0.35) | TRPM8TRPA1OPRM1ALDH1A1CYP3A4 | |
| SCHEMBL10976094 | 0.85 | TRPM8 (0.41) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| SCHEMBL11146809 | 0.85 | TRPM8 (0.41) | TRPM8TRPA1OPRM1ALDH1A1EPHX1 | |
| Hydrochloric Acid SCHEMBL1580278 | 0.84 | MEN1 (0.46) | TRPM8OPRM1ALDH1A1DNM1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998039104-A1 | METHOD FOR TREATING LUMBER | GARAPICK RONALD T (US) | 1998-09-11 | — | — | WO | disclosed |
| US-5783258-A | Method for treating lumber | GARAPICK RONALD T (US) | 1998-07-21 | — | — | US | disclosed |