Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8585253 | 0.86 | TRPM8 (0.43) | ALDH1A1OPRM1TRPM8TRPA1CYP19A1 | |
| SCHEMBL7606663 | 0.85 | TRPM8 (0.44) | ALDH1A1OPRM1TRPM8TRPA1 | |
| Bromide SCHEMBL9486638 | 0.78 | TRPM8 (0.38) | ALDH1A1OPRM1TRPM8TRPA1 | |
| Hydrochloric Acid SCHEMBL8602843 | 0.77 | TRPM8 (0.42) | ALDH1A1OPRM1TRPM8TRPA1CYP19A1 | |
| Hydrochloric Acid SCHEMBL10629698 | 0.77 | TRPM8 (0.42) | ALDH1A1OPRM1TRPM8TRPA1CYP19A1 | |
| Bromide SCHEMBL2472545 | 0.74 | TRPM8 (0.42) | ALDH1A1OPRM1TRPM8TRPA1 | |
| Hydrochloric Acid SCHEMBL14320259 | 0.74 | OPRM1 (0.35) | ALDH1A1OPRM1TRPM8TRPA1 | |
| SCHEMBL11146809 | 0.73 | TRPM8 (0.41) | ALDH1A1OPRM1TRPM8TRPA1 | |
| Hydrochloric Acid SCHEMBL11706695 | 0.72 | MEN1 (0.46) | ALDH1A1OPRM1TRPM8LMNACYP19A1 | |
| Hydrochloric Acid SCHEMBL1580278 | 0.72 | MEN1 (0.46) | ALDH1A1OPRM1TRPM8LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281414-A | Crosslinked organosilicon quarternary ammonium salt and ion exchange resin | STOCKEL RICHARD F (US) | 1994-01-25 | — | — | US | disclosed |