Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942091 | 0.89 | ATM (0.68) | ALDH1A1SMN1; SMN2LMNAGAAATM | |
| SCHEMBL17311791 | 0.84 | MEN1 (0.68) | ALDH1A1SMN1; SMN2LMNANAMPTMEN1 | |
| SCHEMBL6079075 | 0.83 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNAGAACA2 | |
| SCHEMBL6077413 | 0.82 | NPC1 (0.62) | ALDH1A1SMN1; SMN2LMNAGAACA2 | |
| SCHEMBL12334893 | 0.80 | NAMPT (0.79) | NAMPT | |
| SCHEMBL8544004 | 0.79 | F2 (0.70) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL6078001 | 0.79 | IKBKB (0.57) | NAMPTMEN1KMT2AIMPDH2 | |
| SCHEMBL9568645 | 0.78 | HDAC1 (0.62) | ALDH1A1SMN1; SMN2LMNAGAACA2 | |
| SCHEMBL17102987 | 0.78 | MAPT (0.60) | ALDH1A1SMN1; SMN2LMNAGAACA2 | |
| SCHEMBL808105 | 0.78 | ATM (0.72) | ALDH1A1SMN1; SMN2LMNAGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353538-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2015-12-10 | — | — | US | disclosed |
| US-20130317027-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2013-11-28 | — | — | US | disclosed |
| US-20120329786-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353538-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD47, CD4 | ALDH1A1 592/4885SMN1; SMN2 4098/4885LMNA 4409/4885 |
| US-20120329786-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD47, CD4 | ALDH1A1 592/4885SMN1; SMN2 4098/4885LMNA 4409/4885 |
| US-20130317027-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | NFATC1, CD47, CD4 | ALDH1A1 592/4885SMN1; SMN2 4098/4885LMNA 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.