Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19694359 | 0.85 | TBXAS1 (0.43) | VNN1TBXA2RTBXAS1PSMB5AAK1 | |
| SCHEMBL12583014 | 0.76 | MDM2 (0.47) | AAK1NPC1RAB9A | |
| SCHEMBL1829215 | 0.70 | LMNA (0.40) | VNN1TBXAS1PSMB5NPC1RAB9A | |
| SCHEMBL27711856 | 0.69 | TBXAS1 (0.41) | VNN1TBXA2RTBXAS1AAK1GAA | |
| SCHEMBL16576947 | 0.69 | AAK1 (0.44) | AAK1RAB9AKDM4EKMT2AALDH1A1 | |
| SCHEMBL8544873 | 0.68 | IDO1 (0.56) | VNN1NPC1RAB9AGAAPLOD2 | |
| SCHEMBL1515801 | 0.68 | IDO1 (0.56) | VNN1NPC1RAB9AGAAPLOD2 | |
| SCHEMBL14338236 | 0.68 | ADORA3 (0.39) | VNN1PSMB5IDO1KDM4EALDH1A1 | |
| SCHEMBL6496781 | 0.68 | NLRP3 (0.42) | TBXA2RTBXAS1AAK1NPC1GAA | |
| SCHEMBL7824758 | 0.68 | GAA (0.50) | VNN1TBXAS1PSMB5GAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312230-B2 | Carboxylic acid derivatives as IP antagonists | ROCHE PALO ALTO LLC (US) | 2007-12-25 | — | — | US | disclosed |