Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.60 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348408 | 0.84 | CAMK2D (0.68) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL14348390 | 0.84 | JAK2 (0.64) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL8351537 | 0.83 | RXFP1 (0.54) | MAPTRXFP1RAB9ANPC1TP53 | |
| SCHEMBL14348389 | 0.80 | SMG1 (0.56) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL8349127 | 0.79 | BTK (0.56) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL8349795 | 0.77 | KDM4E (0.58) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL8349440 | 0.76 | BTK (0.54) | JAK2JAK3MAPTABL1PDGFRB | |
| SCHEMBL14253908 | 0.75 | ABL1 (0.59) | CAMKK2CAMKK1CAMK2DJAK2JAK3 | |
| SCHEMBL1927424 | 0.75 | PDGFRA (0.62) | ABL1PDGFRBBCRPDGFRAEGFR | |
| SCHEMBL14021128 | 0.74 | PIK3CA (0.55) | CAMK2DJAK2JAK3CNR1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |