Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 8/20 | 0.54 |
| ▸ | PRKCA | P17252 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.52 |
| ▸ | BCR | P11274 | 6/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349127 | 0.93 | BTK (0.56) | BTKABL1PRKCAEGFRPRKCD | |
| SCHEMBL8350684 | 0.85 | MAPK8 (0.55) | HTTKMT2AMAPTUSP2 | |
| SCHEMBL8349795 | 0.85 | KDM4E (0.58) | BTKHTTSYKMAPTJAK2 | |
| SCHEMBL14348390 | 0.82 | JAK2 (0.64) | BTKABL1PRKCAEGFRPRKCD | |
| SCHEMBL27549053 | 0.80 | PDGFRA (0.53) | ABL1PRKCAEGFRPRKCDPDGFRA | |
| SCHEMBL8352521 | 0.77 | ABL1 (0.58) | ABL1PRKCAEGFRPRKCDPDGFRA | |
| SCHEMBL14348407 | 0.77 | CAMK2D (0.72) | ABL1PRKCAEGFRPRKCDPDGFRA | |
| SCHEMBL8350880 | 0.76 | MAPK8 (0.54) | PRKCDHTTKMT2AMAPTPRKCG | |
| SCHEMBL14021215 | 0.76 | HTT (0.59) | ABL1PDGFRABCRPDGFRBHTT | |
| SCHEMBL4382343 | 0.76 | JAK2 (0.64) | ABL1PRKCAEGFRPRKCDPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |