Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.48 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351193 | 0.85 | MAPK10 (0.54) | RXFP1MAPTNPC1RAB9AMAPK10 | |
| SCHEMBL14348392 | 0.83 | CAMKK2 (0.60) | RXFP1MAPTNPC1RAB9ATP53 | |
| SCHEMBL8351171 | 0.82 | MAPK10 (0.58) | MAPTMAPK10MAPK8MAPK14KMT2A | |
| SCHEMBL8351530 | 0.80 | MAPK10 (0.56) | MAPK10MAPK8MAPK14 | |
| SCHEMBL8350880 | 0.78 | MAPK8 (0.54) | MAPTMAPK10MAPK8MAPK14HTT | |
| SCHEMBL8349130 | 0.76 | MAPK14 (0.52) | RXFP1MAPTNPC1RAB9AMAPK14 | |
| SCHEMBL14348419 | 0.76 | ALDH1A1 (0.53) | MAPTNPC1RAB9ATP53MAPK10 | |
| SCHEMBL1518956 | 0.76 | MAPK10 (0.78) | MAPK10MAPK8MAPK14PIP5K1CPIK3CA | |
| SCHEMBL8350684 | 0.73 | MAPK8 (0.55) | MAPTMAPK10MAPK8HTTKMT2A | |
| SCHEMBL3233742 | 0.72 | RXFP1 (0.58) | RXFP1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |