Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 7/20 | 0.56 |
| ▸ | BCR | P11274 | 6/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | PRKCA | P17252 | 5/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.55 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.54 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | PRKCH | P24723 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349127 | 0.86 | BTK (0.56) | JAK2JAK3CAMK2DABL1BCR | |
| SCHEMBL14348392 | 0.84 | CAMKK2 (0.60) | JAK2JAK3CAMK2DABL1BCR | |
| SCHEMBL8349795 | 0.84 | KDM4E (0.58) | JAK2JAK3CAMK2DPIK3CACAMKK2 | |
| SCHEMBL8349440 | 0.82 | BTK (0.54) | JAK2JAK3ABL1BCRSRC | |
| SCHEMBL14253908 | 0.81 | ABL1 (0.59) | JAK2JAK3CAMK2DABL1BCR | |
| SCHEMBL14348389 | 0.81 | SMG1 (0.56) | JAK2JAK3CAMK2DABL1BCR | |
| SCHEMBL4004743 | 0.81 | CAMK2D (0.81) | JAK2JAK3CAMK2DABL1BCR | |
| SCHEMBL4383563 | 0.80 | JAK2 (0.82) | JAK2JAK3ABL1BCRSRC | |
| SCHEMBL8351171 | 0.80 | MAPK10 (0.58) | JAK2PIK3CAMAPK8 | |
| SCHEMBL14253973 | 0.79 | CAMK2D (0.67) | JAK2JAK3CAMK2DABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |