Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.50 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349440 | 0.93 | BTK (0.54) | BTKJAK2JAK3SYKPDGFRA | |
| SCHEMBL8349795 | 0.89 | KDM4E (0.58) | BTKCAMK2DJAK2JAK3SYK | |
| SCHEMBL14348390 | 0.86 | JAK2 (0.64) | BTKCAMK2DJAK2JAK3CAMKK2 | |
| SCHEMBL8352521 | 0.83 | ABL1 (0.58) | CAMK2DJAK2JAK3CAMKK2PDGFRA | |
| SCHEMBL14348407 | 0.83 | CAMK2D (0.72) | CAMK2DJAK2JAK3CAMKK2PDGFRA | |
| SCHEMBL8350880 | 0.82 | MAPK8 (0.54) | JAK2JAK3PIK3CAMAPK8GSK3B | |
| SCHEMBL14348392 | 0.79 | CAMKK2 (0.60) | BTKCAMK2DJAK2JAK3CNR2 | |
| SCHEMBL27549053 | 0.78 | PDGFRA (0.53) | PDGFRAKITABL1EGFRPRKCA | |
| SCHEMBL14253908 | 0.77 | ABL1 (0.59) | BTKCAMK2DJAK2JAK3CAMKK2 | |
| SCHEMBL8350684 | 0.77 | MAPK8 (0.55) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |