SCHEMBL1435843

SCHEMBL1435843

Cc1cc(S(=O)(=O)O)ccc1N=Nc1c(O)ccc2ccccc12.[NaH]

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.69
HIF1A Q16665 3/20 0.69
CYP2C9 P11712 3/20 0.69
TSHR P16473 1/20 0.69
PTPRA P18433 1/20 0.69
PTPRB P23467 1/20 0.69
CYP2C19 P33261 1/20 0.69
RAPGEF4 Q8WZA2 1/20 0.69
HSD17B10 Q99714 1/20 0.69
THRB P10828 2/20 0.67
MAPK1 P28482 4/20 0.63
KMT2A Q03164 3/20 0.63
MAPT P10636 3/20 0.63
TDP1 Q9NUW8 2/20 0.63
GAA P10253 1/20 0.63
MPL P40238 4/20 0.57
CTRC Q99895 2/20 0.57
MEN1 O00255 2/20 0.54
GLO1 Q04760 2/20 0.54
ALDH1A1 P00352 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1435839 1.00 CYP1A2 (0.69) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL12955458 0.99 CYP1A2 (0.71) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL5160460 0.99 CYP1A2 (0.71) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL28547156 0.90 CYP1A2 (0.68) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL751982 0.89 CYP1A2 (0.70) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL8528180 0.89 CYP1A2 (0.70) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL30742587 0.89 CYP1A2 (0.70) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL1435840 0.88 THRB (0.67) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL29625856 0.88 THRB (0.67) CYP1A2HIF1ACYP2C9TSHRPTPRA
SCHEMBL1743198 0.88 THRB (0.67) CYP1A2HIF1ACYP2C9TSHRPTPRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4750804-B2 2011-08-17 JP claimed
US-20080306026-A1 Capsule Formulation SYNGENTA CROP PROTECTION LLC 2008-12-11 US claimed
JP-2008531514-A 2008-08-14 JP claimed
EP-1919439-A2 PROCESS FOR BLEACHING KERATIN FIBERS The Procter and Gamble Company (US) 2008-05-14 EP claimed
EP-1850664-A2 PESTICIDAL CAPSULE FORMULATION Syngeta Participations AG (CH) 2007-11-07 EP claimed
US-20070231283-A1 Process for bleaching keratin fibers PROCTER & GAMBLE COMPANY, THE 2007-10-04 US claimed
WO-2007026327-A2 PROCESS FOR BLEACHING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2007-03-08 WO claimed
EP-1759684-A1 Process for bleaching keratin fibers Wella Aktiengesellschaft (DE) 2007-03-07 EP claimed
WO-2006089747-A2 PRESTICIDAL CAPSULE FORMULATION SYNGENTA PARTICIPATIONS AG (CH) 2006-08-31 WO claimed
US-20050257328-A1 Agent for simultaneously dying and bringhtening keratin fibers WELLA AKTIENGESELLSCHAFT (DE) 2005-11-24 US claimed
EP-2387988-B1 Oxidizing composition for the treatment of keratin fibres PROCTER & GAMBLE (US) 2017-09-27 EP disclosed
US-9204630-B2 Capsule formulation SYNGENTA PARTICIPATIONS AG (CH) 2015-12-08 US disclosed
US-8444706-B2 Oxidizing composition for the treatment of keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2013-05-21 US disclosed
US-20120288459-A1 Oxidizing Composition for the Treatment of Keratin Fibers BURG WILFRIED (DE) 2012-11-15 US disclosed
US-8308822-B2 Oxidizing composition for the treatment of keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2012-11-13 US disclosed
WO-2006081245-A1 AGENTS FOR COLORING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2006-08-03 WO disclosed
WO-2006081244-A2 COLORANTS COMPRISING CATIONIC AZACYANINE DYES THE PROCTER & GAMBLE COMPANY (US) 2006-08-03 WO disclosed
WO-2006081246-A2 USE OF CATIONIC AZACYANINE DYES FOR COLORING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2006-08-03 WO disclosed
US-20050257328-A1 Agent for simultaneously dying and bringhtening keratin fibers WELLA AKTIENGESELLSCHAFT (DE) 2005-11-24 US disclosed
US-20050226838-A1 Hair treatment compositions containing N-hydroxy-alkyl-O-benzyl chitosans and methods of using same WELLA AG (DE) 2005-10-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050226838-A1 Hair treatment compositions containing N-hydroxy-alkyl-O-benzyl chitosans and methods of using same CYP8B1, HAAO, TYR CYP1A2 1409/4885HIF1A 2089/4885CYP2C9 878/4885
US-20120288459-A1 Oxidizing Composition for the Treatment of Keratin Fibers KRT18, CKMT1A; CKMT1B, OAT CYP1A2 2481/4885HIF1A 2916/4885CYP2C9 2441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.