Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 5/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTPRA | P18433 | 1/20 | 0.57 |
| ▸ | PTPRB | P23467 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.54 |
| ▸ | MPL | P40238 | 2/20 | 0.51 |
| ▸ | CTRC | Q99895 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29625856 | 1.00 | THRB (0.67) | THRBPTPN1CYP1A2CYP2C9HIF1A | |
| SCHEMBL1743198 | 1.00 | THRB (0.67) | THRBPTPN1CYP1A2CYP2C9HIF1A | |
| SCHEMBL12955458 | 0.89 | CYP1A2 (0.71) | THRBCYP1A2CYP2C9HIF1AHSD17B10 | |
| SCHEMBL5160460 | 0.89 | CYP1A2 (0.71) | THRBCYP1A2CYP2C9HIF1AHSD17B10 | |
| SCHEMBL1435839 | 0.88 | CYP1A2 (0.69) | THRBCYP1A2CYP2C9HIF1AHSD17B10 | |
| SCHEMBL1435843 | 0.88 | CYP1A2 (0.69) | THRBCYP1A2CYP2C9HIF1AHSD17B10 | |
| SCHEMBL29414559 | 0.88 | CYP1A2 (0.61) | THRBPTPN1CYP1A2CYP2C9HIF1A | |
| SCHEMBL2304218 | 0.88 | CYP1A2 (0.61) | THRBPTPN1CYP1A2CYP2C9HIF1A | |
| SCHEMBL368222 | 0.88 | CYP1A2 (0.61) | THRBPTPN1CYP1A2CYP2C9HIF1A | |
| SCHEMBL11758743 | 0.84 | MAPT (0.61) | THRBPTPN1CYP1A2CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4750804-B2 | — | — | 2011-08-17 | — | — | JP | claimed |
| US-20080306026-A1 | Capsule Formulation | SYNGENTA CROP PROTECTION LLC | 2008-12-11 | — | — | US | claimed |
| JP-2008531514-A | — | — | 2008-08-14 | — | — | JP | claimed |
| EP-1919439-A2 | PROCESS FOR BLEACHING KERATIN FIBERS | The Procter and Gamble Company (US) | 2008-05-14 | — | — | EP | claimed |
| EP-1850664-A2 | PESTICIDAL CAPSULE FORMULATION | Syngeta Participations AG (CH) | 2007-11-07 | — | — | EP | claimed |
| US-20070231283-A1 | Process for bleaching keratin fibers | PROCTER & GAMBLE COMPANY, THE | 2007-10-04 | — | — | US | claimed |
| WO-2007026327-A2 | PROCESS FOR BLEACHING KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2007-03-08 | — | — | WO | claimed |
| EP-1759684-A1 | Process for bleaching keratin fibers | Wella Aktiengesellschaft (DE) | 2007-03-07 | — | — | EP | claimed |
| WO-2006089747-A2 | PRESTICIDAL CAPSULE FORMULATION | SYNGENTA PARTICIPATIONS AG (CH) | 2006-08-31 | — | — | WO | claimed |
| US-20050257328-A1 | Agent for simultaneously dying and bringhtening keratin fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2005-11-24 | — | — | US | claimed |
| EP-2387988-B1 | Oxidizing composition for the treatment of keratin fibres | PROCTER & GAMBLE (US) | 2017-09-27 | — | — | EP | disclosed |
| US-9204630-B2 | Capsule formulation | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-08 | — | — | US | disclosed |
| US-8444706-B2 | Oxidizing composition for the treatment of keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120288459-A1 | Oxidizing Composition for the Treatment of Keratin Fibers | BURG WILFRIED (DE) | 2012-11-15 | — | — | US | disclosed |
| US-8308822-B2 | Oxidizing composition for the treatment of keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2012-11-13 | — | — | US | disclosed |
| EP-1707187-A1 | Reductive colorant for keratin fibres | Wella Aktiengesellschaft (DE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2006089747-A2 | PRESTICIDAL CAPSULE FORMULATION | SYNGENTA PARTICIPATIONS AG (CH) | 2006-08-31 | — | — | WO | disclosed |
| WO-2006081245-A1 | AGENTS FOR COLORING KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2006-08-03 | — | — | WO | disclosed |
| US-20050257328-A1 | Agent for simultaneously dying and bringhtening keratin fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2005-11-24 | — | — | US | disclosed |
| US-20050226838-A1 | Hair treatment compositions containing N-hydroxy-alkyl-O-benzyl chitosans and methods of using same | WELLA AG (DE) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050226838-A1 | Hair treatment compositions containing N-hydroxy-alkyl-O-benzyl chitosans and methods of using same | CYP8B1, HAAO, TYR | THRB 1768/4885PTPN1 2819/4885CYP1A2 1409/4885 |
| US-20120288459-A1 | Oxidizing Composition for the Treatment of Keratin Fibers | KRT18, CKMT1A; CKMT1B, OAT | THRB 2598/4885PTPN1 683/4885CYP1A2 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.