Eosin

Eosin

SCHEMBL1436014

O=C1OC2(c3ccccc31)c1cc(Br)c(O)c(Br)c1Oc1c2cc(Br)c(O)c1Br.[Na].[Na]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 2/20 0.97
AKR1C1 Q04828 1/20 0.63
TDP1 Q9NUW8 5/20 0.60
MEN1 O00255 5/20 0.60
KMT2A Q03164 5/20 0.60
RECQL P46063 3/20 0.60
THRB P10828 2/20 0.60
BLM P54132 2/20 0.60
ACE2 Q9BYF1 2/20 0.60
L3MBTL1 Q9Y468 2/20 0.60
USP2 O75604 2/20 0.60
CDK2 P24941 1/20 0.60
CHAT P28329 1/20 0.60
BLVRB P30043 1/20 0.60
RXFP1 Q9HBX9 1/20 0.60
HSP90AA1 P07900 2/20 0.59
GNG2 P59768 1/20 0.58
GNB1 P62873 1/20 0.58
CYP3A4 P08684 3/20 0.56
ALDH1A1 P00352 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eosin SCHEMBL113395 0.99 PRMT1 (1.00) PRMT1AKR1C1TDP1MEN1KMT2A
Eosin SCHEMBL29350830 0.99 PRMT1 (1.00) PRMT1AKR1C1TDP1MEN1KMT2A
Eosin SCHEMBL29381252 0.99 PRMT1 (1.00) PRMT1AKR1C1TDP1MEN1KMT2A
Eosin SCHEMBL461913 0.97 PRMT1 (0.97) PRMT1AKR1C1TDP1MEN1KMT2A
Eosin SCHEMBL16862387 0.97 PRMT1 (0.97) PRMT1AKR1C1TDP1MEN1KMT2A
SCHEMBL25027302 0.92 PRMT1 (0.86) PRMT1AKR1C1TDP1MEN1KMT2A
SCHEMBL5356623 0.92 PRMT1 (0.86) PRMT1AKR1C1TDP1MEN1KMT2A
SCHEMBL18932171 0.92 PRMT1 (0.86) PRMT1AKR1C1TDP1MEN1KMT2A
SCHEMBL11230115 0.89 PRMT1 (0.82) PRMT1AKR1C1TDP1MEN1KMT2A
SCHEMBL5358935 0.88 PRMT1 (0.80) PRMT1AKR1C1TDP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173829-B2 Compositions for dyeing keratin fibers HENKEL AG & CO. KGAA (DE) 2015-11-03 US disclosed
US-9161898-B2 Compositions for colouring keratin fibres HENKEL AG & CO. KGAA (DE) 2015-10-20 US disclosed
US-20140298592-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS HENKEL AG & CO. KGAA (DE) 2014-10-09 US disclosed
US-20140290690-A1 COMPOSITIONS FOR COLOURING KERATIN FIBRES HENKEL AG & CO. KGAA (DE) 2014-10-02 US disclosed
EP-1844109-B1 USE OF CATIONIC AZACYANINE DYES FOR COLORING KERATIN FIBERS PROCTER & GAMBLE (US) 2011-03-30 EP disclosed
US-7749283-B2 Colorant with nacreous luster for keratin fibers WELLA AG (DE) 2010-07-06 US disclosed
US-7658771-B2 Coloring agents for keratin fibers THE PROCTER & GABLE COMPANY (US) 2010-02-09 US disclosed
US-20100021396-A1 TINTING MOUSSE HENKEL AG & CO. KGAA (DE) 2010-01-28 US disclosed
US-20090172896-A1 dye carrier formulation containing an oxidative dye precursor and/or a direct dye, a combination of a fatty alcohol with 14 to 20 carbon atoms,a fatty alkanolamide, and a fatty alcohol alkoxylate and/or fatty acid alkoxylate; hair dye HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) 2009-07-09 US disclosed
US-7513917-B2 Coloring agents for keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2009-04-07 US disclosed
WO-2006099163-A1 COLOURANTS FOR KERATIN FIBRES COMPRISING CERTAIN CATIONIC CELLULOSE ETHER DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 2006-09-21 WO disclosed
WO-2006081246-A2 USE OF CATIONIC AZACYANINE DYES FOR COLORING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2006-08-03 WO disclosed
WO-2006081244-A2 COLORANTS COMPRISING CATIONIC AZACYANINE DYES THE PROCTER & GAMBLE COMPANY (US) 2006-08-03 WO disclosed
US-20050042712-A1 Methods, compositions and instruments to predict antimicrobial or preservative activity ADVANCED MEDICAL OPTICS, INC. 2005-02-24 US disclosed
US-6793687-B2 YELLOW AND ORANGE RANGE COLORING WELLA AKTIENGESELLSCHAFT (DE) 2004-09-21 US disclosed
US-6600050-B2 Inorganic and organic acids and agents, containing these compounds, for the oxidative dyeing of fibers such as hair for hair dyes WELLA AG (DE) 2003-07-29 US disclosed
US-20030131423-A1 Diaminopyrazole derivatives and oxidation hair dye containing pyrazolone derivatives HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2003-07-17 US disclosed
US-20020189031-A1 Use of salts for improving the absorption qualities of anionic direct dyes WELLA AKTIENGESELLSCHAFT (DE) 2002-12-19 US disclosed
US-6485529-B1 Agent and method for coloring fibers WELLA AKTIENGESELLSCHAFT (DE) 2002-11-26 US disclosed
US-6106579-A MIXTURE OF OXOCARBOXYLIC ACID AND REDUCING AGENT WELLA AKTIENGESELLSCHAFT (DE) 2000-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140290690-A1 COMPOSITIONS FOR COLOURING KERATIN FIBRES KRT18, DSG1, PKN1 PRMT1 780/4885AKR1C1 412/4885TDP1 2441/4885
US-20140298592-A1 COMPOSITIONS FOR DYEING KERATIN FIBERS KRT18, PKN3, IK PRMT1 523/4885AKR1C1 295/4885TDP1 2754/4885
US-20100021396-A1 TINTING MOUSSE KRT18, MSN, MFAP1 PRMT1 1476/4885AKR1C1 1315/4885TDP1 2719/4885
US-20030131423-A1 Diaminopyrazole derivatives and oxidation hair dye containing pyrazolone derivatives KRT18, AOC1, PPOX PRMT1 2141/4885AKR1C1 246/4885TDP1 1595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.