Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363773 | 0.88 | ABCG2 (0.52) | ADRA1AABCB1ABCG2LMNAMAPT | |
| SCHEMBL14363771 | 0.84 | MAPKAPK2 (0.51) | ADRA1AHTR7ABCB1ABCG2MAPT | |
| SCHEMBL14364159 | 0.82 | CHRNA7 (0.55) | ADRA1DADRA1AADRA1BCYP2D6CHRNA7 | |
| SCHEMBL14364171 | 0.79 | CHRNA7 (0.49) | ADRA1DADRA1AADRA1BCYP2D6ABCB1 | |
| SCHEMBL14364157 | 0.79 | CHRNA7 (0.49) | ADRA1DADRA1AADRA1BCYP2D6ABCB1 | |
| SCHEMBL14363777 | 0.76 | MAPT (0.51) | ADRA1DADRA1ACYP2D6HTR7ABCG2 | |
| SCHEMBL14363778 | 0.72 | SLC6A4 (0.39) | ADRA1ACYP2D6ABCB1ABCG2MAPT | |
| SCHEMBL14364158 | 0.71 | ADRA1A (0.62) | ADRA1DADRA1AADRA1BCYP2D6CHRNA7 | |
| SCHEMBL17518851 | 0.69 | ADRA1D (0.64) | ADRA1DADRA1AADRA1BCYP2D6HTR7 | |
| SCHEMBL21648518 | 0.69 | CHRNA7 (0.42) | ADRA1DADRA1AADRA1BABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007147819-A1 | 3H,11H-OXAZOLO[3',4':1,2]PYRIDO[3,4-B]INDOLE DERIVATIVES AND THERAPEUTIC USE THEREOF | FOURTILLAN (FR) | 2007-12-27 | — | — | WO | disclosed |