Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | MAX | P61244 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200448 | 0.88 | ALDH1A1 (0.73) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL14367451 | 0.83 | ALDH1A1 (0.56) | KDM4EALDH1A1HTTMAPTHSD17B10 | |
| SCHEMBL3277995 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL1717948 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL1719321 | 0.76 | HPGD (0.69) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL14014121 | 0.76 | KDM4E (0.78) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL30382020 | 0.75 | KDM4E (0.82) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL1718871 | 0.75 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTHSD17B10CASP1 | |
| SCHEMBL4197490 | 0.73 | KDM4E (0.74) | KDM4EALDH1A1APOBEC3AHTTGAA | |
| SCHEMBL1718395 | 0.73 | KDM4E (0.78) | KDM4EALDH1A1APOBEC3AHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-11-22 | — | — | US | disclosed |
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-11-22 | — | — | US | disclosed |
| EP-1782859-A2 | Pharmaceutical use of substituted pyrazolo [1,5- a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | HSD3B1, HSD11B1, SRD5A1 | KDM4E 3872/4885ALDH1A1 133/4885APOBEC3A 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.