Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | CASP1 | P29466 | 4/20 | 0.54 |
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367444 | 0.86 | ALDH1A1 (0.71) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL14367442 | 0.83 | KDM4E (0.62) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL16614836 | 0.82 | ALDH1A1 (0.60) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1718871 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL14367441 | 0.78 | KDM4E (0.76) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1720125 | 0.77 | KDM4E (0.80) | ALDH1A1HSD17B10SMN1; SMN2HPGDKDM4E | |
| SCHEMBL1718290 | 0.77 | ALDH1A1 (0.76) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1718188 | 0.76 | ALDH1A1 (0.78) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A | |
| SCHEMBL1718621 | 0.75 | HSD17B10 (0.69) | ALDH1A1HSD17B10SMN1; SMN2HPGDKDM4E | |
| SCHEMBL14367447 | 0.74 | ALDH1A1 (0.73) | ALDH1A1HSD17B10SMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-11-22 | — | — | US | disclosed |
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-11-22 | — | — | US | disclosed |
| EP-1782859-A2 | Pharmaceutical use of substituted pyrazolo [1,5- a]pyrimidines | NOVO NORDISK A/S (DK) | 2007-05-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270408-A1 | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines | HSD3B1, HSD11B1, SRD5A1 | ALDH1A1 133/4885HSD17B10 44/4885SMN1; SMN2 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.