Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7191779 | 0.78 | KDM4E (0.46) | NPC1ALDH1A1RAB9AMGAMGAA | |
| SCHEMBL11618175 | 0.76 | ALDH1A1 (0.49) | SLC9A1NPC1ALDH1A1RAB9AMGAM | |
| SCHEMBL3701288 | 0.72 | GRK6 (0.43) | GRK6GRIN2BSLC9A1DHODHPDE10A | |
| Ammonia Solution, Strong SCHEMBL25300630 | 0.70 | GAA (0.42) | NPC1ALDH1A1RAB9AGAAPARP1 | |
| SCHEMBL13824120 | 0.69 | NR4A2 (0.43) | GRK6RAB9A | |
| SCHEMBL3038641 | 0.69 | CES2 (0.46) | GRK6SLC9A1NPC1CCNE2CCNE1 | |
| SCHEMBL1221425 | 0.68 | DYRK1A (0.43) | GRK6GRIN2BSLC9A1NPC1ALDH1A1 | |
| SCHEMBL11622097 | 0.68 | PIN1 (0.50) | GRK6SLC9A1NPC1ALDH1A1PKM | |
| SCHEMBL22321902 | 0.66 | ADORA2B (0.45) | ALDH1A1GAAPARP1CYP1A2CYP2C9 | |
| SCHEMBL3189256 | 0.66 | NPC1 (0.51) | GRK6GRIN2BSLC9A1DHODHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053892-A1 | Imidazo[4,5-d]Pyridazine Compounds For Treating Viral Infections | LEIVERS MARTIN | 2011-03-03 | — | — | US | disclosed |
| WO-2011026024-A2 | IMIDAZO [4,5-D] PYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |
| US-20110052534-A1 | Imidazopyridazine Compounds for Treating Viral Infections | LEIVERS MARTIN | 2011-03-03 | — | — | US | disclosed |
| WO-2011026091-A1 | IMIDAZOPYRIDAZINE COMPOUNDS FOR TREATING VIRAL INFECTIONS | GLAXOSMITHKLINE LLC (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052534-A1 | Imidazopyridazine Compounds for Treating Viral Infections | ACE, ACE2, TPMT | GRK6 2269/4885GRIN2B 2552/4885SLC9A1 3205/4885 |
| US-20110053892-A1 | Imidazo[4,5-d]Pyridazine Compounds For Treating Viral Infections | MAVS, ZC3HAV1, IL5 | GRK6 3469/4885GRIN2B 2936/4885SLC9A1 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.