Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585261 | 0.82 | CA2 (0.42) | PTK2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL334875 | 0.74 | PTK2 (0.38) | PTK2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7555210 | 0.69 | NPSR1 (0.58) | PTK2KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL3044354 | 0.67 | — | — | |
| SCHEMBL4704966 | 0.66 | MAPK1 (0.49) | ALDH1A1MAPTMAPK1L3MBTL1KDM4E | |
| SCHEMBL23531735 | 0.66 | PTK2 (0.36) | PTK2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL4556834 | 0.65 | PRNP (0.45) | PTK2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL1286667 | 0.65 | — | — | |
| SCHEMBL2083893 | 0.64 | PTK2 (0.38) | PTK2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL15782809 | 0.64 | PTK2 (0.38) | PTK2KMT2AALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933354-B1 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-03-30 | — | — | EP | disclosed |
| US-6939895-B2 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| US-6750255-B2 | SUCH AS (R)-N-(1-(1'-NAPHTHYL)ETHYL)-2-(2',5'-DICHOROPHENYL THIO)ETHYLAMINE; FOR STIMULATION OF SECRETION OF PARATHYROID HORMONE | NPS PHARMACEUTICALS, INC. | 2004-06-15 | — | — | US | disclosed |
| US-20030176485-A1 | Calcium receptor active compounds | NPS PHARMACEUTICALS, INC. | 2003-09-18 | — | — | US | disclosed |
| US-20030144526-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. | 2003-07-31 | — | — | US | disclosed |
| US-20020107406-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | US | disclosed |
| US-6362231-B1 | MODULATOR OF PARATHYROID HORMONE; OSTEOPOROSIS | NPS PHARMACEUTICALS, INC. | 2002-03-26 | — | — | US | disclosed |
| EP-0933354-A1 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1999-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144526-A1 | Calcium receptor-active compounds | CASR, CALCR, CNR1 | PTK2 1459/4885KMT2A 2797/4885ALDH1A1 3470/4885 |
| US-20030176485-A1 | Calcium receptor active compounds | CASR, CNR1, CALCR | PTK2 1517/4885KMT2A 2794/4885ALDH1A1 3326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.