Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10341186 | 0.79 | NPSR1 (0.63) | NPSR1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL334875 | 0.77 | PTK2 (0.38) | NPSR1SMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL4704966 | 0.74 | MAPK1 (0.49) | SMN1; SMN2KDM4EALDH1A1PKMTSHR | |
| SCHEMBL3585261 | 0.71 | CA2 (0.42) | SMN1; SMN2KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL1436752 | 0.69 | PTK2 (0.37) | SMN1; SMN2KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL29059142 | 0.66 | CYP2D6 (0.66) | NPSR1SMN1; SMN2KDM4ECYP2D6CYP2C9 | |
| SCHEMBL11502726 | 0.66 | ALDH1A1 (0.48) | NPSR1SMN1; SMN2KDM4ECYP1A2ALDH1A1 | |
| SCHEMBL11502876 | 0.66 | ALDH1A1 (0.48) | NPSR1SMN1; SMN2KDM4ECYP1A2ALDH1A1 | |
| SCHEMBL4761265 | 0.63 | CA12 (0.63) | NPSR1SMN1; SMN2KDM4ECYP1A2CYP2D6 | |
| SCHEMBL7508269 | 0.63 | EDNRA (0.35) | NPSR1KMT2APTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527801-B1 | THIOPHENE SULFONAMIDES USEFUL AS CARBONIC ANHYDRASE INHIBITORS | ALCON LAB INC (US) | 2002-07-31 | — | — | EP | claimed |