Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 9/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349682 | 0.88 | MAP3K12 (0.37) | MAP3K12SYKPIK3CDPIM1PIK3CA | |
| SCHEMBL20676296 | 0.77 | CCR1 (0.42) | MAP3K12PIK3CDPIM1PIK3CALRRK2 | |
| SCHEMBL23365116 | 0.77 | PIK3CD (0.36) | MAP3K12PIK3CDPIM1PIK3CAACVR2A | |
| SCHEMBL29979707 | 0.77 | PIK3CD (0.36) | MAP3K12PIK3CDPIM1PIK3CAACVR2A | |
| SCHEMBL24620393 | 0.75 | MGLL (0.39) | MAP3K12SYK | |
| SCHEMBL23365111 | 0.74 | PIK3CD (0.36) | MAP3K12PIK3CDPIM1PIK3CAACVR2A | |
| SCHEMBL29979625 | 0.74 | PIK3CD (0.36) | MAP3K12PIK3CDPIM1PIK3CAACVR2A | |
| SCHEMBL25147093 | 0.74 | CHRNA7 (0.40) | MAP3K12PIK3CDPIM1PIK3CALRRK2 | |
| SCHEMBL14376103 | 0.74 | NOS3 (0.41) | MAP3K12PIK3CDPIM1PIK3CALRRK2 | |
| SCHEMBL3230699 | 0.71 | MAP3K12 (0.53) | MAP3K12PIM1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |