Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.62 |
| ▸ | RAB9A | P51151 | 12/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355528 | 0.88 | KMT2A (0.66) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL10383130 | 0.79 | ALDH1A1 (0.50) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL30828585 | 0.79 | RAB9A (0.54) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL15846834 | 0.78 | NPC1 (0.66) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL31709720 | 0.78 | NPC1 (0.66) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL12310125 | 0.78 | RAB9A (1.00) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL822378 | 0.78 | RAB9A (1.00) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL15214321 | 0.78 | RAB9A (1.00) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14580374 | 0.78 | RAB9A (1.00) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL27181403 | 0.78 | RAB9A (1.00) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |