Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14375912 | 0.81 | NAMPT (0.52) | NAMPTTP53MAPTNPC1KMT2A | |
| SCHEMBL14375898 | 0.81 | PDGFRA (0.51) | NAMPT | |
| SCHEMBL14375872 | 0.75 | PDGFRA (0.60) | — | |
| SCHEMBL14375921 | 0.73 | MAPT (0.41) | TP53MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL14375835 | 0.73 | MAPK14 (0.48) | — | |
| SCHEMBL14375923 | 0.71 | ABL1 (0.43) | NAMPTDDB1CRBNHTTNPC1 | |
| SCHEMBL14375922 | 0.71 | NPC1 (0.62) | TP53MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL14375917 | 0.69 | ALDH1A1 (0.72) | TP53MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL10355528 | 0.69 | KMT2A (0.66) | TP53MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL14375914 | 0.67 | CA12 (0.40) | MAPTNPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279576-B2 | Anti-cancer medicaments | DECIPHERA PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |