Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14426975 | 0.89 | HSD11B1 (0.41) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL2376127 | 0.85 | HSD11B1 (0.44) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL14378224 | 0.84 | PSIP1 (0.41) | HSD11B1AKR1B1PSIP1KDM4EMEN1 | |
| SCHEMBL2903593 | 0.83 | HSD11B1 (0.45) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL4004824 | 0.81 | HSD11B1 (0.44) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL2376126 | 0.81 | HSD11B1 (0.44) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL272465 | 0.81 | HSD11B1 (0.44) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL27688701 | 0.81 | HSD11B1 (0.44) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL272000 | 0.80 | HSD11B1 (0.43) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 | |
| SCHEMBL5407429 | 0.78 | SLC6A2 (0.43) | HSD11B1SLC22A12SLC6A2SLC6A4STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232654-A1 | Novel Compounds and Compositions as Cathepsin Inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232654-A1 | Novel Compounds and Compositions as Cathepsin Inhibitors | CTSS, CTSB, CTSE | HSD11B1 3874/4885SLC22A12 2625/4885SLC6A2 3130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.