SCHEMBL14394646

SCHEMBL14394646

Bc1ccc(NS(=O)(=O)c2ccccc2)c(C(=O)Nc2ccc(F)c(F)c2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR27 Q9NS67 8/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
BDKRB1 P46663 1/20 0.49
SLC10A2 Q12908 2/20 0.49
SLC10A1 Q14973 2/20 0.49
SLC10A6 Q3KNW5 2/20 0.49
AVPR2 P30518 1/20 0.49
TP53 P04637 1/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
MCL1 Q07820 2/20 0.48
KDM4E B2RXH2 2/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
HPGD P15428 1/20 0.48
CRHBP P24387 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14113178 0.87 SLC10A6 (0.67) GPR27MEN1KMT2ABDKRB1SLC10A2
SCHEMBL7537204 0.76 MAPT (0.51) GPR27MEN1KMT2ABDKRB1AVPR2
SCHEMBL6860368 0.75 AVPR2 (0.60) GPR27MEN1KMT2ABDKRB1SLC10A2
SCHEMBL7120319 0.74 SLC10A6 (0.76) GPR27MEN1KMT2ASLC10A2SLC10A1
SCHEMBL19155062 0.73 ALDH1A1 (0.55) MEN1KMT2AKDM4EALDH1A1LMNA
SCHEMBL7572279 0.73 FFAR4 (0.73) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL1138705 0.73 SLC10A6 (0.63) GPR27MEN1KMT2ASLC10A2SLC10A1
SCHEMBL7212991 0.73 SLC10A6 (0.73) GPR27MEN1KMT2ABDKRB1SLC10A2
SCHEMBL14113153 0.73 SLC10A6 (0.63) GPR27MEN1KMT2ASLC10A2SLC10A1
SCHEMBL7123083 0.73 MEN1 (0.67) GPR27MEN1KMT2ABDKRB1SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1839655-A1 CTGF EXPRESSION INHIBITOR Shionogi Co., Ltd. (JP) 2007-10-03 EP disclosed