Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL234545 | 0.87 | ALOX12 (0.51) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL5266878 | 0.84 | ALOX12 (0.48) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL5271608 | 0.84 | ALOX12 (0.48) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL4175173 | 0.83 | ALDH1A1 (0.63) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL234246 | 0.83 | KDM4E (0.67) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL19236369 | 0.81 | ALOX12 (0.62) | KDM4EHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL14396312 | 0.81 | ABCB1 (0.61) | KDM4EALDH1A1ALOX15ALOX12KCNA3 | |
| SCHEMBL29036860 | 0.79 | KDM4E (1.00) | KDM4EHPGDALDH1A1USP2HSD17B10 | |
| SCHEMBL678221 | 0.78 | ALOX15 (0.78) | KDM4EHPGDALDH1A1HSD17B10ALOX15 | |
| SCHEMBL9755691 | 0.77 | ALDH1A1 (0.63) | KDM4EHPGDALDH1A1USP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |