SCHEMBL234545

SCHEMBL234545

O=c1c(-c2ccccc2O)coc2cc(O)c(Cl)cc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.51
ALOX15 P16050 1/20 0.51
NPSR1 Q6W5P4 2/20 0.49
PPARG P37231 2/20 0.49
LMNA P02545 2/20 0.49
NCOA2 Q15596 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
NCOR2 Q9Y618 1/20 0.49
KDM4E B2RXH2 4/20 0.48
ALDH1A1 P00352 4/20 0.48
HPGD P15428 3/20 0.48
HSD17B10 Q99714 3/20 0.48
USP2 O75604 2/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.47
POLB P06746 2/20 0.47
MIF P14174 2/20 0.46
CYP3A4 P08684 2/20 0.45
GLA P06280 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14396124 0.87 KDM4E (0.65) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL5266878 0.87 ALOX12 (0.48) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL5271608 0.87 ALOX12 (0.48) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL4175173 0.87 ALDH1A1 (0.63) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL234246 0.84 KDM4E (0.67) ALOX15PPARGKDM4EALDH1A1HPGD
SCHEMBL678221 0.81 ALOX15 (0.78) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL2942244 0.79 ALOX12 (0.62) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL19236369 0.79 ALOX12 (0.62) ALOX12ALOX15NPSR1PPARGLMNA
SCHEMBL18825571 0.79 HDAC6 (0.70) ALOX12ALOX15PPARGKDM4EALDH1A1
SCHEMBL232753 0.79 KDM4E (0.74) ALOX15NPSR1PPARGLMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120003273-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) 2012-01-05 US claimed
EP-2346844-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS Council Of Scientific & Industrial Research (IN) 2011-07-27 EP claimed
WO-2010052734-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-05-14 WO claimed
EP-2346844-B1 SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL SCIENT IND RES (IN) 2017-09-20 EP disclosed
EP-2346844-B1 SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL SCIENT IND RES (IN) 2017-09-20 EP disclosed
US-20120003273-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) 2012-01-05 US disclosed
US-20120003273-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) 2012-01-05 US disclosed
US-20120003273-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) 2012-01-05 US disclosed
EP-2346844-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS Council Of Scientific & Industrial Research (IN) 2011-07-27 EP disclosed
WO-2010052734-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-05-14 WO disclosed
WO-2010052734-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-05-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120003273-A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS AKR1C3, AKR1C4, SLC10A1 ALOX12 1465/4885ALOX15 1264/4885NPSR1 772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.