Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678221 | 0.89 | ALOX15 (0.78) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL11082015 | 0.88 | ALOX12 (0.77) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL234545 | 0.87 | ALOX12 (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL2942244 | 0.86 | ALOX12 (0.62) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL19236369 | 0.86 | ALOX12 (0.62) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL14396312 | 0.85 | ABCB1 (0.61) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL5267926 | 0.85 | EGFR (0.54) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL5266770 | 0.85 | RAB9A (0.64) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL5266878 | 0.83 | ALOX12 (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL5271608 | 0.83 | ALOX12 (0.48) | ALDH1A1SMN1; SMN2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192152-A1 | Novel Antigiardial Agents and Methods of Use Thereof | UNIVERSITY OF MISSISSIPPI | 2009-07-30 | — | — | US | disclosed |
| US-7468445-B2 | Antigiardial agents and use thereof | UNIVERSITY OF MISSISSIPPI (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |
| US-20060106091-A1 | Antigiardial agents and use thereof | THE UNIVERSITY OF MISSISSIPPI | 2006-05-18 | — | — | US | disclosed |
| US-20050222230-A1 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2005-10-06 | — | — | US | disclosed |
| EP-1456180-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | Vernalis (Oxford) Ltd (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2004014886-A1 | ANTIGIARDIAL AGENTS AND USE THEREOF | UNIVERSITY OF MISSISSIPPI (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2003055860-A1 | 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2003-07-10 | — | — | WO | disclosed |
| CN-1129445-A | Isoflavone derivatives | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1996-08-21 | — | — | CN | disclosed |
| EP-0710234-A1 | ISOFLAVONE DERIVATIVES | CHINOIN LTD. (HU) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003293-A1 | ISOFLAVONE DERIVATIVES | CHINOIN LTD. (HU) | 1995-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106091-A1 | Antigiardial agents and use thereof | GPER1, ENPP2, ALPI | ALDH1A1 2026/4885SMN1; SMN2 3704/4885RAB9A 1440/4885 |
| US-20090192152-A1 | Novel Antigiardial Agents and Methods of Use Thereof | ENPP2, GPER1, ALPI | ALDH1A1 2472/4885SMN1; SMN2 4129/4885RAB9A 1314/4885 |
| US-20050222230-A1 | 3,4-diarylpyrazoles and their use in the therapy of cancer | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 986/4885SMN1; SMN2 4757/4885RAB9A 3155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.